Instrumentation

Instruments

Lumora is able to help partners develop custom hardware specified to their customers' needs through the application of our experience generated over many years of research and development. Instrumentation development can represent a major hurdle to new product release, but Lumora is experienced in helping partners bring commercial systems to market rapidly.

We have developed two generations of hardware to perform Bioluminescent Assays in Real-Time, which are now being used to develop assays and demonstrate the performance capabilities of BART. Whilst the underlying amplification and measurement principles are the same, there are a number of bespoke differences in their use:

Current platforms

Through the development of multiple instrument platforms we have developed a thorough understanding of both the technology capabilities and user requirements, which allow us to support partners in their specification of products.

Small Instrument (PDQ)

PDQPDQ, Lumora has developed a highly portable instrument, likely the simplest ever for molecular amplification and detection, which is straight-forward to manufacture and easy to operate. Underneath its casing the PDQ platform consists of a heater block for isothermal reactions and an array of "off-the-shelf" photodiodes for real-time bioluminescent reading, making it incredibly robust yet meaning cost of goods is remarkably low. An algorithm for data interpretation is built to provide easy-to-interprate results for users, whilst sample data can be inputted & outputted quickly using the full colour touch screen and the built in SD card reader.

If you are interested in either of these cutting edge solutions then please contact us via partnering@lumora.co.uk

High Throughput Development System

Bison, We have also developed a laboratory system capable of imaging high density arrays of simultaneous reactions, using the popular microwell plate format.Bison These instruments are routinely used for screening and down-selection of primer designs for inclusivity, exclusivity and general performance characteristics. They can be made available to licensees and other research and development collaborators for external development activities.

In addition, this digital camera based system has also been used with 1534 well plates in proof-of-concept studies for Digital BART

Expertise

Our knowledge of heating control and temperature measurement systems and CCD and photodiode optical systems can be applied to your own specific instrument requirements.

Algorithms

Lumora uses an in-house developed algorithm for interrogation of BART signals, which uses a unique signal motif to increase confidence in reported results.

Partnerships

As well as our internal capabilities, we have a number of strategic, local partnerships for instrumentation design and development such as with Panchromos.

Future Platforms

Lumora is currently exploring a number of technical solutions for the splitting of samples to enable automated detection of multiple pathogens in parallel. This will offer significant benefits in areas such as respiratory infections and sexual health screens.

In addition, we are also adapting the image sensing Bison platform to concepts for digital analysis, which will enable absolute quantification in applications such as rare mutation detection and copy number analysis. Digital BART has the potential to transfer these research applications into routine diagnostic procedures by dramatically reducing the cost and complexity of associated instrumentation.

 

If you are interested in either of these cutting edge solutions then please contact us via partnering@lumora.co.uk